Infertility

Facing Challenges on the Path to Parenthood?

If you’ve been trying to conceive for a while without success, it’s understandable to feel frustrated or discouraged. It’s important to remember you’re not alone – many couples face similar challenges.

The inability to get pregnant after one year of unprotected sex is considered infertility. While the cause can sometimes be difficult to pinpoint, a fertility clinic can help explore potential reasons. These can range from hormonal imbalances to anatomical issues in both men and women.

The good news is there are many effective treatments available to significantly increase your chances of getting pregnant. Fertility clinics specialise in providing these options, including hormone therapy, medications, and surgery. In some cases, assisted reproductive techniques can be explored to help with fertilisation.

 

Moving Forward

If you’re facing infertility challenges, a fertility clinic can be a valuable resource. They have the expertise to diagnose the cause and recommend personalised treatment plans to help you achieve your dream of parenthood. Remember, you’re not alone in this journey, and there is hope.

The main symptom of infertility is not getting pregnant. There may be no other obvious symptoms. Sometimes, women with infertility may have irregular or absent menstrual periods. In some cases, men with infertility may have some signs of hormonal problems, such as changes in hair growth or sexual function.

It’s important to talk to your doctor if you have concerns about your fertility. Women, especially, should consider seeking professional guidance earlier if they:

Women should talk with a care provider earlier, however, if they:

  • Are 35 or older and haven’t conceived after six months of trying.
  • Are over 40 years old.
  • Have irregular or absent menstrual periods.
  • Experience very painful periods.
  • Have a history of fertility issues.
  • Have been diagnosed with endometriosis or pelvic inflammatory disease.
  • Have had multiple miscarriages.
  • Have undergone cancer treatment.

Men should also talk to their doctor if they have:

  • Low sperm count or other sperm-related problems.
  • A history of testicular, prostate, or sexual problems.
  • Undergone cancer treatment.
  • Notice small or swollen testicles.
  • Have a family history of infertility.

Conception involves a remarkable journey. For pregnancy to occur, a sperm needs to meet and fertilise an egg in one of the fallopian tubes. This fertilised egg then travels to the uterus, where it implants itself in the lining. Let’s take a closer look at the male and female reproductive systems to understand where potential roadblocks might arise.

The Male Reproductive System:

The male reproductive system is responsible for producing, storing, and delivering sperm. Testicles produce sperm, which is then mixed with fluids from the seminal vesicles and prostate gland to form semen. During intercourse, the penis ejaculates semen, hopefully containing sperm that can reach and fertilise an egg.

The Female Reproductive System:

The female reproductive system consists of the ovaries, fallopian tubes, uterus, cervix, and vagina. The ovaries produce eggs, the fallopian tubes transport eggs, the uterus nourishes a fertilised egg, the cervix acts as a passageway, and the vagina is the birth canal.

Potential causes of female infertility may include:

  • Ovulation disorders, which affect the release of eggs from the ovaries. These include hormonal disorders such as polycystic ovary syndrome. Hyperprolactinemia, a condition in which you have too much prolactin — the hormone that stimulates breast milk production — also may interfere with ovulation. Either too much thyroid hormone (hyperthyroidism) or too little (hypothyroidism) can affect the menstrual cycle or cause infertility. Other underlying causes may include too much exercise, eating disorders or tumors.
  • Uterine or cervical abnormalities, including abnormalities with the cervix, polyps in the uterus or the shape of the uterus. Noncancerous (benign) tumors in the uterine wall (uterine fibroids) may cause infertility by blocking the fallopian tubes or stopping a fertilized egg from implanting in the uterus.
  • Fallopian tube damage or blockage, often caused by inflammation of the fallopian tube (salpingitis). This can result from pelvic inflammatory disease, which is usually caused by a sexually transmitted infection, endometriosis or adhesions.
  • Endometriosis, which occurs when endometrial tissue grows outside of the uterus, may affect the function of the ovaries, uterus and fallopian tubes.
  • Primary ovarian insufficiency (early menopause), when the ovaries stop working and menstruation ends before age 40. Although the cause is often unknown, certain factors are associated with early menopause, including immune system diseases, certain genetic conditions such as Turner syndrome or carriers of Fragile X syndrome, and radiation or chemotherapy treatment.
  • Pelvic adhesions, bands of scar tissue that bind organs that can form after pelvic infection, appendicitis, endometriosis or abdominal or pelvic surgery.
  • Cancer and its treatment. Certain cancers — particularly reproductive cancers — often impair female fertility. Both radiation and chemotherapy may affect fertility.

PATIENT INFORMATION ON THE IVF/ICSI PROGRAM

In Vitro Fertilization (IVF) is a process whereby by which fertilization occurs outside of the body of the female.

Intracytoplasmic sperm injection (ICSI) is a process wherein a sperm is injected into the egg.

Traditionally, the IVF/ICSI cycle starts on the first day of the menstrual cycle.
Blood tests are done to confirm that the hormone levels are baseline.

On the 2nd day of the period, a consultation with the doctor is necessary to scan the lining of the womb, the ovaries and to confirm that the pelvis has no other pathologies.

Putting all variables together, the doctor will recommend medication and the cycle chart depending on the baseline findings.

Follow-up blood tests and scans may be required depending on the growth of eggs, usually midcycle and end before egg collection.

Once the leading eggs have reached a size considered full for follicular growth, a process that takes a minimum of 10days and can extend beyond that for the eggs to be fully mature, the final injection will be taken precisely at the time as directed by the doctor. This injection will lead to final maturation of eggs and cause ovulation.

At this stage, a time of egg collection will be given to the patient/couple so that the eggs are collected before they are released from the follicles.

Possible side effects of fertility medication
• Skin irritation at the injection site
• Nausea and bloating
• Breast tenderness
• Mild Headaches
• Malaise/fatigue/.tiredness

Fertility Treatment does not:
Increase the risk of breast cancer or any other cancers

Fertilisation, preparation of gametes, the development, and growth of embryos:
On the day of egg collection, preferably just before, a sperm sample is required for fertilisation.

At the laboratory, the eggs are fertilized by the IVF process or alternatively by the process of ICSI depending on the diagnosis and circumstances.

The fertilized eggs are checked after 24hours and fertilisation is confirmed. Usually, the couple is kept informed at some stages of the progress in the embryo laboratory.

Depending on the circumstances, the developing embryos are replaced in the uterus on the 3rd or the 5th day after egg collection.

What can go wrong during embryo development?

Female factors
Advanced female age using autologous (own) eggs
Women who did not respond well to stimulation (poor responders)
Hydrosalpinx (fluid in the tube)
Lifestyle – smoking, drinking, nutrition, weight (overweight, underweight)

Male factors
Advanced male age
Sperm DNA fragmentation
Genetic syndromes
Lifestyle – smoking, drinking, nutrition, overweight

Embryonic factors
Egg and embryo quality – egg maturity at collection determines the quality and size of embryo
Embryo biopsy especially at day3 of growth
Use of frozen-thawed eggs
Eggs that are slow to fertilize and divide
Abnormal cell division

Lab and medium related factors
Lab temperature,
pH,
air quality,
aerosols,
light,
embryo culture medium

COLLECTION OF EGGS
(Oocyte Retrieval/Ovum Pick-up/Transvaginal Oocyte Aspiration)

The procedure is done in an operating room/theatre under deep sedation or light general anaesthesia.

It is done under ultrasound guidance, using a needle to collect the egg and the fluid that surrounds the egg.

Once all the mature follicle have been aspirated, the patient is fully awake and taken to the recovery room for a couple of hours.

Prior to discharge:
the patient is given something to eat, the nurses make sure they can pass urine and that all their vital signs are stable.

In some instances, there may be a small amount of spotting after the procedure, not lasting more than one day.

At home, the patient must feel comfortable, even though they may experience mild to moderate pain after the procedure.

Pain medication will be given before discharge.
Should the pain not alleviate or get progressively worse, the patient must either inform the clinic or present to the nearest emergency department.

Before the procedure
Please make sure you understand and carefully follow instructions
You must be fasted for at least 6 hours(no food)
Please leave all valuables at home
You need a companion to be with you before and after the procedure
You will be asked to empty your bladder before going into theatre
Please mention all or any pre-existing medical conditions you may have
Please mention all medication you are currently taking, including the fertility medication, blood thinners, homeopathic medication or alternative medications like herbs etc..
Please mention any allergies or previous reactions to medication

After the procedure
You will be in the recovery room to rest until you are fully awake.
Your vital signs will be checked every 30min
You will be offered something small to eat and/or drink
You will be asked to empty your bladder before you go home
You will be given instructions on what to do in case of emergency
You will be informed of the number of eggs collected
You will be provided a sick note for at least 48hours only, unless otherwise changes are necessary

Possible risks and side-effects of egg collection
• Premature ovulation
This will lead to failure to collect eggs as they have already been released from the follicles
• Empty Follicle Syndrome
In rare cases, some eggs stick to the wall of the follicle and are not amenable to collection.

Further, it is postulated that the ovulation trigger may have not worked properly or on time

• Ovarian Hyperstimulation Syndrome (OHSS)
Ovarian hyperstimulation syndrome is a potentially serious complication of fertility treatment, particularly of in vitro fertilisation (IVF?ICSI).

It can range from mild to severe. Mild OHSS is common and usually gets better with time.

Severe cases of OHSS require specialist care and hospital admission.

Your fertility Specialist will discuss the above with you in full during a consultation

Risk Factors

Age

Women's fertility gradually declines with age, especially in the mid-30s, and it drops rapidly after age 37. Infertility in older women is likely due to the lower number and quality of eggs, and can also be due to health problems that affect fertility. Men over age 40 may be less fertile than younger men.

Tobacco use.

Smoking tobacco or marijuana by either partner may reduce the likelihood of pregnancy. Smoking also reduces the possible effectiveness of fertility treatment. Miscarriages are more frequent in women who smoke. Smoking can increase the risk of erectile dysfunction and a low sperm count in men.

Alcohol use.

For women, there's no safe level of alcohol use during conception or pregnancy. Alcohol use may contribute to infertility. For men, heavy alcohol use can decrease sperm count and motility.

Being overweight.

Among women, an inactive lifestyle and being overweight may increase the risk of infertility. For men, sperm count also may be affected by being overweight.

PREPARING FOR EMBRYO TRANSFER

In modern IVF, it is favoured to freeze the embryos and prepare the body for embryo transfer in a new cycle that has not been affected by hormonal injections.

The embryo transfer is often, but not always done under ultrasound guidance.

It is done in a tranquil procedure room, the patient is allowed to rest for a while, then go home when they are ready.

The patient may need to use hormone preparations (progesterone and oestrogen) as directed until a pregnancy test is done, 10-12 days after the embryo transfer.

Once confirmed to be positive, the supporting hormones are continued until the doctor directs the patient to taper down or stop.

If the pregnancy test is negative, all fertility medication is stopped.

The patient requires a follow-up appointment to review the cycle with the doctor.

What can go wrong during embryo transfer?

A full bladder is required to assist the procedure.
For some women, this is very uncomfortable, but the bladder is emptied immediately after the embryo is placed in utero by the doctor.

The cervix (entry to the womb) may be too tight or shut if not previously assessed. This is avoided by assessing the cervix when egg collection is done.

The angle between the cervix and the uterus may be too sharp/curved

The embryo may stick to the delivery catheter, requiring the procedure to be repeated

All the above are not complications but challenges that are usually easily overcome

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